Protein Details: Voltage-gated sodium channel subunit beta-2

Protein ID

ICDB_Pro_0236

Protein Name

Voltage-gated sodium channel subunit beta-2

Gene Name

SCN2B; UNQ326/PRO386

Organism

Homo sapiens (Human)

Length

215 amino acids

AlphaFoldDB

AF-O60939-F1-model_v4.pdb

Function

Crucial in the assembly; expression; and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).

Sequence

MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNHKQFSLNWTYQECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPEDEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK

PDB Structures

5FDY 5FEB 6J8E 6J8G 6J8H 6J8I 6J8J 6VRR 7W77 7W7F 7W9K 7W9L 7W9M 7W9P 7W9T 7XM9 7XMF 7XMG 7XVE 7XVF 8G1A 8GZ1 8GZ2 8I5B 8I5G 8I5X 8I5Y 8S9B 8S9C

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

56;135

Disease

Atrial Fibrillation;Familial;14 and Brugada Syndrome

Location

Central Neurons; peripheral neurons; heart; glia

DOI ID

10.1126/science.aaw2493

RefSeq

NP_004579.1